An official website of the United States government. Careers. -, Yuan J.P., Peng J., Yin K., Wang J.H. Inclusion in an NLM database does not imply endorsement of, or agreement with, Results from Clinical Trials. Consult with your doctor before starting an astaxanthin supplement. Shimokawa T., Yoshida M., Fukuta T., Tanaka T., Inagi T., Kogure K. Efficacy of high-affinity liposomal astaxanthin on up-regulation of age-related markers induced by oxidative stress in human corneal epithelial cells. In another multicenter, prospective, open-label randomized study, AMD patients treated with a combination of lutein/zeaxanthin and astaxanthin over a two-year period were more likely to report a significant improvement in visual acuity, contrast sensitivity and vision-related functions [41]. Before Licensee MDPI, Basel, Switzerland. ii On top of this, an additional study involving 49 healthy volunteers found that those taking 4mg or 12mg of astaxanthin a. ); moc.liamg@98iebanreb.ociredef (F.B. According to the TFOS DEWS II published in 2017, dry eye disease (DED) is a multifactorial disease of the ocular surface characterized by the loss of homeostasis of the tear film and ocular symptoms, in which tear film instability and hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities play etiological roles (. Furthermore, another study evaluated the effects of astaxanthin, zeaxanthin, lutein, -carotene and lycopene on lipid peroxidation [9]. To date, evidence of astaxanthin use in the setting of age-related cataract, which represents the most common subtype of cataract encountered in clinical practice, is still missing. Zhang L., Wang H. Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. Kat Burki Complete B Bio-Correcting Face Creme $390.00 $312.00. McNulty H., Jacob R.F., Mason R.P. Recent findings of increased plasma levels of oxidative markers in NAION patients suggest the key role of oxidative processes in the pathogenesis of disturbed small-vessel autoregulation in posterior ciliary circulation, which then leads to vascular insufficiency and subsequent optic nerve head ischemia [50]. As a result, astaxanthin administration significantly decreased the production of NO, PGE2, and TNF- by directly blocking NOS enzyme activity [44]. Data from both preclinical and clinical studies suggest the importance of an equilibrate and complete nutrition to support eye health. Increased flux of polyol pathways, enhanced formation of advanced glycation end products (AGEs), upregulated hexosamine pathway and PKC activation result in the augmentation of oxidative agents, which then induce vascular dysfunction including membrane thickening, pericyte drop out and retinal capillary nonperfusion with subsequent retinal ganglion cell loss [16]. Biologic activity of carotenoids related to distinct membrane physicochemical interactions. Evaluating the maximum safe daily intake of AX is important when setting dose levels for these products and currently, there are discrepancies in recommendations by different regulatory authorities. Antioxidants, such as vitamin A and other carotenoids, can help reduce the risk of age-related eye health issues. Skeletal structure of astaxanthin that consists of a ,-carotene-4,4-dione bearing two hydroxy substituents, Representative images of ocular conditions, Representative images of ocular conditions that may benefit from the use of astaxanthin:, MeSH official website and that any information you provide is encrypted doi: 10.1002/mnfr.201000414. Early research study reveals that taking 40 mg of astaxanthin (AstaCarox by AstaReal AB) daily for 4 weeks lowers reflux symptoms in individuals with indigestion. Would you like email updates of new search results? Furthermore, astaxanthin treatment restored altered VEP parameters, which may be considered as a sensitive and reliable method to evaluate the earliest changes in the visual system occurring in case of elevated IOP [32]. Because of this important biologic activity, apoptosis acts as a key pathogenic factor in several age-related human conditions, such as neurodegenerative disorders, ischemic stroke and heart disease [24]. Mar Drugs. Effects of Carotenoids on Health: Are All the Same? Due to its unique molecular structure, astaxanthin features some important biologic properties, mostly represented by strong antioxidant, anti-inflammatory and antiapoptotic activities. The site is secure. Astaxanthin is one of the most powerful antioxidants found in nature, and it possesses superior qualities for eye support. Piermarocchi S., Saviano S., Parisi V., Tedeschi M., Panozzo G., Scarpa G., Boschi G., Lo Giudice G., Carmis Study Group Carotenoids in Age-related Maculopathy Italian Study (CARMIS): Two-year results of a randomized study. Yang M., Chen Y., Zhao T., Wang Z. Cicero A.F., Allkanjari O., Busetto G.M., Cai T., Largan G., Magri V., Perletti G., Robustelli Della Cuna F.S., Russo G.I., Stamatiou K., et al. ); moc.liamg@3innes.c (C.S. In addition, enhanced apoptosis was detected in all the groups with elevated IOP in contrast to that one treated with astaxanthin, which showed a significant reduction of apoptotic cells percentage. . 2023 May 12;15(10):2283. doi: 10.3390/nu15102283. Zuma Nutrition's Eye Support Tonic Antioxidant activities of astaxanthin and related carotenoids. Astaxanthin appears to be recommended in the dosage range of 6-8mg daily, which is low enough that an enriched salmon oil or krill oil supplement may contain adequate levels. Current therapy for glaucomatous patients is mostly based on IOP-lowering medications; however, this treatment strategy may not be sufficient to stop the progression of the disease, since various other mechanisms including also oxidative stress may take part in the pathogenesis of glaucomatous damage [47]. Several recent clinical trials highlight the potential role of astaxanthin in promoting eye health, as suggested by the significant improvement in the outcomes of various ocular diseases including diabetic retinopathy, age-related macular degeneration, glaucoma and cataract. Ambati R.R., Phang S.M., Ravi S., Aswathanarayana R.G. 8600 Rockville Pike * Astaxanthin For Eye Fatigue and Computer Eye Strain 4. Our Subscription customers are always in the front of the line, so when our stock is low, your favorite products are prioritized for shipment, automatically. Reduced Eye Fatigue Blue light, generated by smartphones, e-readers, laptops, and other high-tech devices, can cause your eyes to get tired. Furthermore, it concomitantly decreased cellular oxidative stress as demonstrated by the reduction of 8-hydroxy-deoxyguanosine (8-OHdG) levels [39]. National Library of Medicine Schleicher M., Weikel K., Garber C., Taylor A. Scorcia V., Soda M., Lucisano A., Lanza M., Giannaccare G. A Preliminary Comparative Study of Visual Performance Between Two Newly Commercially Available Monofocal Intraocular Lenses Implanted During Cataract Surgery. Reduces risk of infertility Also Astaxnthin effectively reduce oxidative damage to DNA, decrease the risk for many types of cancer and stabilize blood sugar. Shop. Lee S.J., Bai S.K., Lee K.S., Namkoong S., Na H.J., Ha K.S., Han J.A., Yim S.V., Chang K., Kwon Y.G., et al. Researched by : Kamal Patel Last Updated: September 28 2022 Summary Dosage Information Examine Database Research feed Research breakdown References 1 [14,15,16]. Skeletal structure of astaxanthin that consists of a ,-carotene-4,4-dione bearing two hydroxy substituents at positions 3 and 3. I took astaxanthin for several years as a supplement plus lutein and other supplements recommended for eye sight and prevention of eye disease. It has been reported that astaxanthin can suppress H2O2-induced NF-B activation by inhibiting intracellular ROS accumulation. Interestingly, mice were daily supplemented with astaxanthin (100 mg/kg/day) either before or after inducing oxidative stress in the retina by photodynamic treatment. AST also offers a dose-independent reduction in mitochondrial injuries and a dose-dependent inhibition of apoptosis in a HIR newborn mouse model. The efficacy of this carotenoid in the setting of retinal diseases, ocular surface disorders, uveitis, cataract and asthenopia is reported in numerous animal and human studies, which highlight its ability of modulating several metabolic pathways, subsequently restoring the cellular homeostatic balance. Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis. Careers, Unable to load your collection due to an error. In addition, as reported by Macedo and coauthors, astaxanthin significantly improves neutrophil phagocytic and microbicidal capacity mostly by reducing deleterious effects of oxidative stress and by increasing intracellular calcium concentration [20]. Astaxanthin benefits on eye health have been studied in both animal models and humans, demonstrating positive effects on . Kimura A., Namekata K., Guo X., Noro T., Harada C., Harada T. Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis. Dry eye: An inflammatory ocular disease. VisionMDs first-of-its-kind formula is formulated to help with age-related eye issues. Products sold on 1MD.org are not intended to diagnose, treat, cure, or prevent any disease. Otsuka T., Shimazawa M., Inoue Y., Nakano Y., Ojino K., Izawa H., Tsuruma K., Ishibashi T., Hara H. Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models. Ease of Use. This is especially common in smokers as tobacco can deplete the vitamins that antioxidants need. ; supervision, G.G. doi: 10.3390/md12010128. Unable to load your collection due to an error, Unable to load your delegates due to an error. Carotenoids have been praised for a long time with regards to the benefits they have for eye health. Abdelazim K, Ghit A, Assal D, Dorra N, Noby N, Khattab SN, El Feky SE, Hussein A. Pharmacol Rep. 2023 May 13:1-20. doi: 10.1007/s43440-023-00488-y. The cleansing properties of astaxanthin allow it to support pancreatic cell activity to promote healthy blood sugar levels. Zhang S., Tang M.B., Luo H.Y., Shi C.H., Xu Y.M. and transmitted securely. Lin W.N., Kapupara K., Wen Y.T., Chen Y.H., Pan I.H., Tsai R.K. Inoue Y., Shimazawa M., Nagano R., Kuse Y., Takahashi K., Tsuruma K., Hayashi M., Ishibashi T., Maoka T., Hara H. Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration. Chronic oxidative stress and inflammation are considered main causes of diabetic retinopathy, which is the most serious sight-threatening complication of diabetes. Astaxanthin For Diabetic Retinopathy 8. and transmitted securely. Astaxanthin, a xanthophyll carotenoid, is a secondary metabolite naturally synthesized by a number of bacteria, microalgae, and yeasts. Conversely, the beneficial activity of astaxanthin has been recently investigated in the setting of an experimental mouse model of cataract due to hyperglycemia and long-time steroid use. Overall rating 2.7. Uveitis, which is an umbrella term describing a wide group of inflammatory conditions affecting the middle layer of the eye, is a common cause of vision loss and eye pain. Such inflammatory cascade is invariably associated with increased oxidative stress. Unauthorized use of these marks is strictly prohibited. All authors have read and agreed to the published version of the manuscript. This site needs JavaScript to work properly. As a result, the supplemented group reported improvement of both NPA and subjective symptoms, such as stiff shoulders or neck and blurred vision. When taken regularly, astaxanthin also helps promote visual acuity (ability to see fine detail). Mahajan N., Arora P., Sandhir R. Perturbed Biochemical Pathways and Associated Oxidative Stress Lead to Vascular Dysfunctions in Diabetic Retinopathy. Benefits Foods Supplement Recommendations Dosage Side Effects and Risks History You may have heard of the carotenoids and antioxidants beta-carotene, lycopene, zeaxanthin, lutein and canthaxanthin, but have you heard of astaxanthin? Benefits of Astaxanthin for Eyes 1. Indeed, astaxanthin has been shown to induce cancer cell apoptosis through a mitochondrial-dependent pathway [25]. Astaxanthin: A review of its chemistry and applications. Astaxanthin helps to protect against typical oxidative stress to the joints, to promote healthy mobility, flexibility, and movement. Boulton M., Dayhaw-Barker P. The role of the retinal pigment epithelium: Topographical variation and ageing changes. There is a growing body of evidence suggesting the beneficial pleiotropic effects of astaxanthin in the prevention and treatment of several ocular diseases, ranging from the anterior to the posterior pole of the eye. [65] studied the pharmacokinetics of astaxanthin by administering a single dose of 40 mg astaxanthin to healthy male volunteers, either as a commercially available food supplement or as lipid based formulations. Due to its unique ability to cross the blood brain/eye barrier, astaxanthin is able to deposit onto the macula of the eye, allowing it to provide support and protection to the cells responsible for vision from the harsh effects of blue light. Yang C.H., Albietz J., Harkin D.G., Kimlin M.G., Schmid K.L.