vol. Bacterial or viral infection has been proposed as a potential risk factor, and there is supporting although not entirely consistent epidemiologic and basic science evidence to support its role. Longitudinal decline in striatal dopamine transporter binding in 100025, Beijing We and our partners share information on your use of this website to help improve your experience. Because the benefits and risks of COVID-19 vaccines do not appear to be different than in the general population, we recommend COVID-19 vaccination with approved vaccines to persons with PD, unless there is a specific contraindication. It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average article of the journal is. Coverage history of this journal is as following: 2011-2021. Many of the documents cited in this story come from an expert report authored by David Michaels, an occupational health expert and a former top health official in both the Clinton and Obama administrations. An ISSN is a unique code of 8 digits. Parkinson's Disease IS is increased by a factor of 0.6 and approximate percentage change is 25.21% when compared to preceding year 2020, which shows a rising trend. or intracellular alpha-synuclein could be efficient in limiting the aggregation and transmission. The presentation to the EPA concluded that paraquat had no effect in the brain and that a causal relationship between paraquat and Parkinsons was not supported. However, the potential of NEAT1 as a biomarker and as a therapeutic target for PD highly warrants further research to elucidate its exact role in this neurodegenerative disorder. Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E, von Coelln R, Simn-Snchez J, Schulte C, Sharma M, Krohn L, Pihlstrm L, Siitonen A, Iwaki H, Leonard H, Faghri F, Gibbs JR, Hernandez DG, Scholz SW, Botia JA, Martinez M, Corvol JC, Lesage S, Jankovic J, Shulman LM, Sutherland M, Tienari P, Majamaa K, Toft M, Andreassen OA, Bangale T, Brice A, Yang J, Gan-Or Z, Gasser T, Heutink P, Shulman JM, Wood NW, Hinds DA, Hardy JA, Morris HR, Gratten J, Visscher PM, Graham RR, Singleton AB (2019) Identification of novel risk loci, causal insights, and heritable risk for Parkinsons disease: A meta-analysis of genome-wide association studies. 11, no. In header section. But a memorandum from a lawyer advising Syngenta suggests that the work was not independent. Syngenta asserts that the allegations lack merit. Moreover, in light of recent advances in the field of personalized medicine, patient stratification according to the degree of mitochondrial impairment followed by mitochondrial enhancement therapy may hold potential for at least a subset of genetic and idiopathic PD cases. J Neural Transm (Vienna) 105, 645676. With alpha-synuclein pathology being strongly associated with dopaminergic neuronal toxicity, strategies aimed to reduce its burden are expected to be beneficial in slowing disease progression. Parkinson's disease (PD) is one of the most common neurodegenerative diseases. 2021 Table of Contents: 2021 Parkinson's Disease - Volume 2021 - Article ID 8610285 - Review Article Cognitive Impairment in Genetic Parkinson's Disease A. Planas-Ballv | D. Vilas 30 Dec 2021 PDF Citation Parkinson's Disease - Volume 2021 - Article ID 3366870 - Review Article J Parkinsons Dis. Parkinson's disease represents a fast-growing neurodegenerative condition; the rising prevalence worldwide resembles the many characteristics typically observed during a pandemic, except for an infectious cause. It looks like the paraquat maker has adopted nearly every strategy we outlined in our book about bending science, McGarity said. This journal has an h-index of 53. We include all trials of agents in Phases 1, 2, and 3. . The latest SCImago Journal Rank (SJR) of Journal of Parkinson's Disease is 1.311. Several active and passive immunization strategies have been explored to target alpha-synuclein. Impact Factor 5.568 by WOS Ranking 1570 by WOS Journal of Parkinson's Disease SJR, SJR Impact Factor and H Index H Index 53 SJR 1.747 Scopus Impact Factor 4.848 You are using a browser version with limited support for CSS. To obtain A Syngenta communication describing the work of its Swat team. There is a growing interest in identifying common traits which lead to the disease. When asked in the deposition if the information presented to the EPA was a lie, Dixon said that Syngenta was not hiding the results of the Marks studies from the EPA, but was instead choosing to focus on other studies. Among these genes, the microtubule-associated protein tau (MAPT ) is the risk locus with the strongest effect size on sporadic PSP in the case-control Paraquat has been shown in some research to increase the risk of Parkinsons by 150% and is cited in a 2020 book, Ending Parkinsons Disease, by four of the worlds leading neurologists as a causal factor for the disease. To achieve that goal, the company set several objectives, including attempting to influence future work by external researchers where possible. 2014;54:141-64. doi: 10.1146/annurev-pharmtox-011613-135937. Paraquat has been shown in some research to increase the risk of Parkinson's by 150% and is cited in a 2020 book, Ending Parkinson's Disease, by four of the world's leading neurologists as a . The https:// ensures that you are connecting to the 9-30, 2021, Authors: Smeyne, Richard J. The Netherlands, Tel: +31 20 688 3355 Thus, in the second part of this review, we discuss therapeutic approaches targeting mitochondrial dysfunction with the aim to prevent or delay neurodegeneration in PD. Article Commentary, Abstract: It meets all the essential criteria of ISO 4 standard. It has been proposed that NEAT1 propagates PD via its interaction with PINK1 and several micro RNAs and by modulating SNCA expression. Evolution of the total number of citations and journal's self-citations received by a journal's published documents during the three previous years. 2005 Mar;62(3):353-7. doi: 10.1001/archneur.62.3.353. Bacterial, viral, and fungal infection-related risk of Parkinson's disease: Meta-analysis of cohort and case-control studies. Clinical Trial Highlights Parkinsons Disease Cognition, Infection and Risk of Parkinsons Disease, Mitochondria and Parkinsons Disease: Clinical, Molecular, and Translational Aspects, Treating Parkinsons Disease with Antibodies: Previous Studies and Future Directions, Genetics of Progressive Supranuclear Palsy: A Review, Neuropathological and Biomarker Findings in Parkinsons Disease and Alzheimers Disease: From Protein Aggregates to Synaptic Dysfunction. Journal Self-citation is defined as the number of citation from a journal citing article to articles published by the same journal. Mitochondrial dysfunction represents a well-established player in the pathogenesis of both monogenic and idiopathic Parkinsons disease (PD). the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in But the scientific record they point to as proof of paraquats safety is the same one that Syngenta officials, scientists and lawyers in the US and the UK have worked over decades to create and at times, covertly manipulate, according to the trove of internal Syngenta files reviewed by the Guardian and the New Lede. The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. A key goal was to create an international scientific consensus against the hypothesis that paraquat is a risk factor for Parkinsons disease, the documents state. Journal of Parkinson's Disease is published by IOS Press BV. It considers the number of citations received by a journal and the importance of the journals from where these citations come. Housenger did not respond to a request for comment. Epub 2020 Feb 4. in Parkinsons disease patients is reported to be about 1.6-fold higher than in a control population in some studies. Epub 2013 Jan 4. ISSN: 1877-7171. . Impact of age at onset on symptom profiles, treatment - Nature PDF Citation Parkinson's Disease - Volume 2023 - Article ID 3104425 - Research Article Prevalence and Factors Associated with Drooling in Parkinson's Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group Diego Santos-Garca | Teresa de Deus Fonticoba | . These contradictory results could be due to the different disease models implemented. doi: 10.1002/brb3.1549. SCImago Journal Rank is an indicator, which measures the scientific influence of journals. these concerns, based on our interpretation of the literature plus the unfolding experience with widespread vaccination in the population at large. The arrival of these vaccines has created hope for people with Parkinsons disease (PD), as this can help to mitigate their risk of becoming infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to serious, life-threatening disease, at least among those with more advanced PD. The h-index is defined as the maximum value of h such that the given journal/author has published h papers that have each been cited at least h number of times. NEAT1 on the Field of Parkinsons Disease: Offense, Defense, or a Player on the Bench? It is based on Scopus data and can be a little higher or different compared to the impact factor (IF) produced by Journal Citation Report. Scientists who study Parkinsons disease have established that symptoms develop when dopamine-producing neurons in a specific area of the brain called the substantia nigra pars compacta (SNpc) are lost or otherwise degenerate. Parkinsons disease (PD) is the second most common neurodegenerative disease worldwide. JPD has a Journal Impact Factor of 5.520, a 5-Year Impact Factor of 6.135, and a Journal Citation Indicator of 0.90 (2021 Journal Citation Reports, source: Clarivate, 2022). Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical presentations. Evolution of the number of total citation per document and external citation per document (i.e. If your research field is/are related to Neurology (clinical) (Q1); Cellular and Molecular Neuroscience (Q2), then CSF synaptic markers are attractive, still needing more evidence, which currently suggests those might be non-specific markers of disease progression. Parkinsons disease (PD) is thought to be caused by a combination of genetic and environmental factors. Would you like email updates of new search results? Searching for just a few words should be enough to get started. It is computed in the year 2022 as per its definition and based on Scopus data. Data Source: Scopus, Explore, visually communicate and make sense of data with our, Metrics based on Scopus data as of April 2023. Though PSP is generally regarded as sporadic, there is increasing evidence suggesting that a series of common and rare genetic variants impact on sporadic and familial forms of PSP. An ISSN is an 8-digit code used to identify newspapers, journals, magazines and periodicals of all kinds and on all media-print and electronic. Monsanto, for example, was found to have ghostwritten scientific studies about a widely used chemical called glyphosate, the active ingredient in Monsantos Roundup herbicide. OFF periods typically manifest as a return of motor symptoms but can also involve non . Berry co-authored a paper published in 2010 titled Paraquat and Parkinsons Disease in Cell Death & Differentiation, a journal owned by the Nature Portfolio, It concluded that the link between paraquat and Parkinsons was weak and evidence linking the chemical to the disease was limited and based on insufficient data. Carey Gillam is managing editor of the New Lede and the author of two books addressing glyphosate: Whitewash (2017) and The Monsanto Papers (2021), Original reporting and incisive analysis, direct from the Guardian every morning, 2023 Guardian News & Media Limited or its affiliated companies. 31-43, 2021, Authors: Borsche, Max | Pereira, Sandro L. | Klein, Christine | Grnewald, Anne, Abstract: genome-wide association studies (GWAS). Considering the devastating symptoms, high prevalence, and lack of definitive diagnostic test, there is an urgent need to identify possible biomarkers and new therapeutic targets. Biological plausibility for the role for infectious agents is supported by the known neurotropic effects of specific viruses, particular vulnerability of the substantia nigra and even the promotion of aggregation of alpha-synuclein. Interest/demand of researchers/scientists for publishing in a specific journal/conference. Enter journal title, issn or abbr in this box to search. 71-92, 2021, Authors: Wen, Yafei | Zhou, Yafang | Jiao, Bin | Shen, Lu, Abstract: This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. Research and Reviews in Parkinsonism an international, peer reviewed, open access journal focusing on presenting current information about Parkinsonism related research, policy, phenomenology, literature, history and treatment. Eradication of the infection improves levodopa response in Parkinsons disease, likely as a consequence of an increased oral pre-systemic bioavailability of levodopa, likely to be explained by reduced Helicobacter-dependent levodopa consumption in the stomach. vol. Syngenta had to turn the records over to plaintiffs lawyers as part of court-ordered discovery. The concept of 'idiopathic' Parkinson's disease (PD) as a single entity has been challenged with the identification of several clinical subtypes, pathogenic genes and putative causative environmental agents. Dr. Savica receives research support from the National Institute on Aging, the National Institute of Neurological Disorders and Stroke, and the Mayo Clinic Small Grants Program National Center for Advancing Translational Sciences (NCATS) and Acadia Pharmaceuticals Inc. Dr. Noyce is funded by the Barts Charity. He said the paper reflected the views of the authors based on the available data at the time. This journal has received a total of 1853 citations during the last three years (Preceding 2021). Parkinsonism Relat Disord 16, 566571. This journal is a member of and subscribes to the principles of the Committee on Publication Ethics. Encephalitis caused by influenza has included parkinsonian features. All types of documents are considered, including citable and non citable documents. (2 years)). Bookshelf Here, proteins encoded by the autosomal recessively inherited PD genes Parkin , PTEN-induced kinase 1 (PINK1 ), and DJ-1 are involved in mitochondrial pathways. Epidemiological evidence is most compelling for an association between PD and hepatitis C virus. 1013 BG Amsterdam official website and that any information you provide is encrypted government site. The company has indicated in court records that its defense will rely in part on the EPAs position that after evaluating hundreds of studies the regulatory agency has not found a clear link between paraquat exposure and Parkinsons disease.
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